Welcome To Chirosolve!
Based in the Silicon Valley, California, USA, ChiroSolve, Inc. began with a simple mission: offering productivity tools and services to help scientists develop chirally pure drugs. The company was started by Dr. Niteen Vaidya, a recognized expert in chiral resolution using diastereomeric crystallization. Dr. Vaidya, understanding the problems and complexities involved in Chiral Separation, used his over 30 years of experience in the field to design high-throughput screening solutions in the form of ChiroSolv® kits.
ChiroSolv® kits are based on the technique of Diastereomeric Crystallization, and can be used with racemates of type acids, bases, alcohols, amino acids, aldehydes and ketones. The kits offer many advantages, such as:
- Very fast screening of racemate against 384 combinations of resolving agents and solvents, offering results within 24 hours. Effectively, work can be finished in days rather than months
- Consistent research environment and accurate results, greatly increasing the chance of project success
- Resolving agents are chosen with manufacturing in mind, and as such they are relatively inexpensive and are readily recoverable in high yields after completion of the resolution process
- Elimination of human errors: the kits design allows maximum automation during as well as after the experiment
Since the introduction of these ChiroSolv® kits, and due to overwhelming customer demand, the company now offers 3 types of Chiral Enhancement Services. These new services allow ChiroSolv® to forge a much closer relationship with customers and become an integral part of their Chiral Resolution research
- Initial Screening: Using Chirosolv® kits, we screen the racemate against 384 combinations of resolving agents and solvents and recommend the best 2-3 combinations that would provide maximum yield and optical rotation
- Identification of separation process: This is the follow up service after initial screening that identifies the number of re-crystallization steps needed to achieve the desired enantiomeric purity. The goal of this service is to identify which method best achieves the desired purity for the target +ve or -ve enantiomer and offers the maximum yield with a minimum number of re-crystallization steps
- Method Optimization through crystal analysis: This service complements both of the above services and can be ordered together. We can identify the optimum concentration of solvent; ideal ratio of racemate to resolving agent; and exact high and low temperature during separation
