ENANTIOPREP (duration 7 to 10 days)
EnatioPrep service offers quick delivery of enantiopure compound for medicinal chemistry needs within matter of days. ChiroSolve "Screen" kits and "Purify" kits are used to perform the work in 3 steps:
Screening: Using 4 Chirosolve kits, the racemate is screened against 384 combination of resolving agents/solvents; and best separation candidate is selected among them
Recovery: Using the ChiroSolve Purify kit components, up to 90% of the racemate used during the screening is recovered from its diastereomeric salts for further purification
Purification: Using the ChiroSolve Purify kit components and the selected combination of resolving agent and solvent from the screening test, the recovered racemate is purified using series of re-crystallization steps. This involves treating the increasingly purified enantiomer mixture with the selected solvent; heating and cooling the mixture; and extracting the further purified enantiomeric crystals. These steps are repeated until enantiomer with target (or highest) purity is obtained
Note: All our services are considered “research projects” and we cannot guarantee that the enantiomeric purity will be achieved. Work is done under best-effort basis.
Performance
- Up to 90% of the racemate used during screening can be recovered; maximizing the use of racemtae to deliver pure enentiomer
- Pure enantiomer obtained after repeated re-crystallization may yield up to 1/3rd quantity of the racemate used
- Up to 5 gm. of pure enantiomer and detailed step-by-step separation method can be developed within matter of days
Key Benefits
- Quick turn-around time to receive pure enantiomer using consistent and robust technology
- Gives "Peace of mind" knowing that the method being defined can be easily scale-up and optimized
- No additional set-up, or investment of expensive instrument needed if larger quantities of enantiomer are needed
