ChiroSolve Products
ChiroSolve provides cost efficient solutions that identify a comprehensive set of chiral separation options; deliver pure enantiomer; and define a chiral separation method scalable to kilo-quantities. Solutions draw from a broad and proven set of Chirosolve products and services to deliver just the right components to best realize chiral separation objectives.
All products employ the ubiquitous technique of diastereomeric crystallization to deliver robust, cost efficient racemate separation with high purity and high yield. This is done by exploring an unprecedented range of separation conditions coupled with rapid methods prioritization strategy and novel purification processes.
ChiroSolve's kit-based solutions are based on the specific research needs as follows:
SCREEN - Identification Of Chiral Separation Conditions
As a first step towards chiral separation method development, the Screen Solutions product line identifies effective separation criteria through comprehensive screening of the racemate against 384 separation conditions. Racemate can have one or more chiral centers; and can be an acid, base, alcohol, aldehyde, ketone or amino acid.- Standard Kits - Set of 4 kits offer 384 unique separation conditions per racemate
- Strong Acid Kits – Set of 2 kits offer 192 unique separation conditions for a weak base racemate
- Kits For Automation – Made from flat-bottom glass vials that are compatible with any HPLC/UPLC system; these set of 4 kits require only 2 mmol racemate for comprehensive screening. Allow full automation during the experiment.
EnantioPrep - Delivery Of Pure Enantiomer
For Medicinal Chemists and Development Scientists, the EnantioPrep product line provides for the rapid preparation of purified enantiomers for discovery, preclinical and early stage clinical testing.Components:
ScalePrep - Optimized Method Development
For Process Development and Scale Up Chemists the ScalePrep product line enables optimization of the separation method for scale up and manufacturing.Components:
- Screen – Comprehensive screening using 384 unique reagent combinations to identify separation conditions
- Purify – Recover racemate after screening and deliver target enantiomer through a series of re-crystallizations
- Optimize – Refine the separation method to find the fastest route and to maximize the enantiopure yield
