ChiroSolv® Kits
Kits are based on an acid-base neutralization technique. Their purpose is to identify which resolving agent and solvent combination offers maximum enantiomeric yield as well as highest specific rotation.
Based on these principles and goals, the kits have been designed as follows:
- Four Acid kits: These kits contain a group of chirally pure acids. They are used to resolve racemic bases. Each kit includes 8 types of acids and 12 types of solvents. All of the acids used in these kits are easily available in bulk quantities and are commonly used in manufacturing processes
- Four Base kits: These kits contain a group of chirally pure bases (or amines). They are used to resolve racemic acid racemates. Each kit includes 8 types of amines and 12 types of solvents. All of the amines used in these kits are easily available in bulk quantities and are commonly used in manufacturing processes Please note that these kits can also be used for neutral racemates of type alcohols, amino acids, aldehydes and ketones, after some pre-processing, as described here
- Kits for liquid racemates: Each of the 96 vials contain a unique combination of resolving agent and solvent in pre-calibrated amount that would ensure maximum enantiomeric yield. The scientist just has to add the racemate into the vials to start the separation.
- Kits for solid racemates: Each vial contains the resolving agent, while the solvents are provided in a separate 96-well plate. A scientist simply dispenses the solid racemate and evaporates that solvent before adding the ChiroSolv® solvents provided in a separate plate. The purpose of this design is to allow a scientist to easily dispense solid racemates.
Depending on the type of racemate you are working with, the kits are available in two formats:
