Screening (Duration: 3 to 5 days)
Target racemate is screened using 4 kits against 384 combinations of resolving agents/solvents. In some cases, we may customize the kits to include specific resolving agents or solvents if the racemate properties are known.
If the racemate is a weak base, strong acid kits are used. Glass Vial Kits" that only require 2 mmol of racemate (as opposed to 12 mmol racemate needed by standard kits) may be used if only a small amount of racemate is available.
Results are provided in terms of product yield and specific rotation values on a digital polarimeter. We also identify two or three of the highest purity-and-yield combinations for scale-up.
Note: All our services are considered “research projects” and we cannot guarantee that target enantiomeric purity will be achieved. Work is done on a best-effort basis.
Performance
- Over the years, ChiroSolve has performed over 100 screening projects with 100% success rate
- Sample racemate can have one or more chiral centers; and be of type acid, base, alcohol, aldehyde, ketone and amino acid.
Key Benefits
- Confidence in selecting candidates for product development and strategies
- Establish an IP foundation
- Easy, rapid preparation of enantiomer for early lead optimization and preclinical testing
