Chiral Enhancement Services
ChiroSolve, Inc. offers a range of services that complements the ChiroSolv® product line.
Initial Screening
The goal of this service is to identify, out of 384 combinations, the specific combinations of resolving agents and solvents that are most ideal for optimal chiral separation.ChiroSolv® kits are used to provide this enhancement service. The given racemate is screened against 384 combinations of resolving agents/solvents. In some cases, if the racemate is weakly base; or if it is a conglomerate, we may use the strongly acid kits; or solvent kits respectively. Results are provided in terms of product yield and specific rotation values on a digital polarimeter. This report includes identification of two or three of the most effective combinations that would give the maximum enantiomeric purity and the highest yield during scale-up operation. Work is done on best-effort basis, and under full confidentiality. Up to 24 mmol of racemate is needed for this service.
Method Development and process optimization
This is a follow-up service after the initial screening. The goal of this service is to identify the optimal separation process that yields maximum amount of enantiomer of specified purity with minimum number of re-crystallization steps.
Using the results of the screening service, bench-top scale-up is done to ensure that the required enantiomeric purity can be achieved. We also analyze the factors that influence the quality and quantity of enantiomer and that can also reduce the manufacturing steps, resulting in tremendous savings: These factors are:
1. Optimum temperature during heating and cooling2. Ratio between the racemate and the resolving agent
3. Percent concentration of the solvent (to water) used during separation
Work is done on best-effort basis, and under full confidentiality.
Method optimization using “Green” techniques
After identifying the separation process, we can explore further process optimization with following goals:
• Avoiding the use of toxic amines• Eliminating or minimizing the use of solvents or resolving agents (for conglomerates)
• Using derivatives of selected resolving agent to achieve higher purity/yield
• Minimizing chemical waste
Note: All our services are considered “research projects” and we cannot guarantee that the enantiomeric purity will be achieved. Work is done under best-effort basis.
