ChiroSolve Services
ChiroSolve, Inc. offers a full range of services that complement the ChiroSolve's kit-based product line. We understand the challenges facing medicinal and process chemists, and are committed to becoming their trusted, value-building outsourcing partner.
During early drug discovery, creating the enantiomer itself can be difficult and expensive. Scientists must make use of the racemate with minimal waste while identifying the resolution method. Effective lead identification requires a focus on generating gram amounts of pure enantiomer.
Process development, on the other hand, seeks to find the robust and scalable method that is safe, cost effective, and that minimizes the manufacturing steps.
ChiroSolve Services
Screening (Duration: 3 days) Target racemate is screened against 384 combinations of resolving agents/solvents that represent most promising commercially viable separation conditions. The results include comprehensive list of separation candidates (ideal for IP scoping) and the recommend combination offering highest yield and purity.
EnantioPrep (Duration: 1 weeks) This service includes the comprehensive screening. But it also recovers the racemate used during screening and then isolates and purifies the target isomer (+ve and/or -ve) to deliver desired purity.
ScalePrep (Duration: 2 weeks) This service explores the optimization factors of the 3 best chiral separation candidates to identify the ideal concentration of solvent and ideal ratio between racemate and the resolving agent that would offer highest yield and purity. The end result is a robust scale-up process that can used to develop kilo quantities of enantiomers.
