Fast-track Small Molecule R&D
Your R&D Partner From Drug Discovery to Process Optimization
Know most commercially viable chiral-separation conditions
Have more options available during process optimization
Most comprehensive IP coverage to cover possible separation conditions
Adopt Green Chemistry
WHAT IF I:
Need to study each enantiomer in chiral compound?
When you screen your racemate against the ChiroSolve kits, you will be able to identify separation conditions for both positive and negative isomers. After you perform the screening and get the crystals, simply liberate the enantiomers from their diastereomeric salts for specific rotation using a polarimeter and note the positive and negative rotations.
Have very little amount of racemate sample?
ChiroSolve has designed "glass-vial kits" specifically to address this need. These high-throughput kits are fully compatible with most HPLC machines and can be fed directly to achieve full-automation. Needing only 0.005 mmol racemate per vial, the kits are of types: acid, base and strong acid.
Have an isomer that I am not able to enrich beyond 80%?
Many times, you can not go beyond certain enantiomeric purity for chiral molecules using chromatography or SFC, and must use diastereomeric crystallization to go beyond that purity level. Employing the diastereomeric crystallization technique through our services, ChiroSolve can achieve this by repeating the recrystallization steps along with crystal initiation techniques, until the final purity is achieved.
Have a racemate with multiple chiral centers?
ChiroSolve has a proven track record of delivering most of the isomers within the multi-center chiral compounds. One such such example was the pesticide Cypermethrin, which had 3 chiral centers and 10 isomers. ChiroSolve was successful in delivering gram quantities of 8 isomers with over 96% EE purity
Need to file patent urgently that covers most chiral separation conditions?
When you screen your racemate against the ChiroSolve kits, you will be able to identify most commercially viable separation conditions for both positive and negative isomers within 24 hours. This is true because our kits offer up to 384 chiral separation conditions in form of resolving agent-solvent combinations, pre-measured into the vials, instantly ready to be used as soon as you add the right amount of racemate into the vials. All you need for the experiment is the hot-water bath, multi-channel pipette, and optionally the ice-bath.
Have a weakly base compound or neutral compound (alcohol, aldehyde, ketone)?
ChiroSolve has designed "Strong Acid Kits" specifically to be used against the weak base compounds. The package comes with 2 reagent plates containing strong acids, together providing 192 commercially viable conditions for the racemate.