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ChiroSolve Screening Kits
ChiroSolve Screening Kits
ChiroSolve employs the ubiquitous technique of diastereomeric crystallization to deliver a robust, cost efficient, and high purity solution. It offers 384 different commercially viable chiral separation options to screen the racemate against in form of high-throughput Screening Kits. The kits support racemate of any type (acid, base, alcohols, aldehydes, ketones, etc.) and can even be used against the molecules with multiple chiral centers.
Depending on the properties of the racemate, the Screening kits can identify most commercially viable chiral separation conditions for both positive and negative isomers within 24 hours (actual hands-on work: 1 hour). For a neutral racemate, pre-processing of the racemate is required to bring it to either acidic or basic moiety before using the ChiroSolve kits.
Kits can be categorized into:
Standard Kits: Vials made of polypropylene; resultant crystals can be seen with naked eye; require 3 mmol racemate per plate
Glass vial Kits (for low quantity of racemate ): Vial size is compatible with any HPLC/UPLC system (for automated analysis); requires only 0.5 mmol racemate per plate
Strong Acid kits (For weak base racemates): These kits contain strong acids; and are available in either of the above two formats
Key features:
Key features:
4 kits per racemate, offering 384 combinations of resolving agents and solvents to screen against
Disposable standard high-throughput kits accommodate easy robotic manipulation
Heat and chemical-resistant kit material can withstand -20 to 450 degree C, whole experiment can be done inside the kit
Kits have long shelf life (up to 10 years at room temperature)
Very little amount of racemate is needed (0.001 to 0.03 mmol per vial)
Key benefits:
Key benefits:
Chiral separation method defined in matter of days
Works against any racemate (acid, base, alcohol, aldehyde, ketone, amino acid, racemate with multiple chiral centers)
Comprehensive screening ensures unbiased results, offers many process optimization options
Early identification of most separation conditions establishes IP foundation
Method development takes days rather than months
Our Customers: Discovery and early process development departments within pharmaceutical and agrochemical companies, CROs, as well as virtual companies looking for small quantities of pure isomers for project feasibility studies.
Our Customers: Discovery and early process development departments within pharmaceutical and agrochemical companies, CROs, as well as virtual companies looking for small quantities of pure isomers for project feasibility studies.
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