Chirally-pure isomers can be obtained using a variety of chiral technologies. The most commonly used is the classic resolution by Diastereomeric Crystallization. Because of its easy adoption in manufacturing environment, most companies try this approach first. Currently, 65% of all chiral products are developed using this technique. ChiroSolvï¿½ helps researchers achieve resolution by Diastereomeric crystallization. The main challenge facing the companies involved in chiral research using diastereomeric crystallization is the selection of an optimum combination of resolving agents and solvents. This is a time consuming, labor intensive and error-prone process. There are hundreds of combinations to choose from and having a consistent research environment is critical to the success of the research.
ChiroSolve allows scientists to quickly screen resolving agents and solvents to find the most optimum combination and to optimize reaction conditions in order to separate a racemic mixture (acids, bases, alcohols, amino acids, aldehydes, ketones) into its constituent enantiomers. It does this by offering six types of kits, each with 12 rows of 8 vials (total 96 vials). Each vial contains a pre-measured quantity of a unique combination of resolving agent and solvent. As a result, scientists can potentially screen 576 combinations of the resolving agents and solvents, if all six types of kits are used at the same time.
Resolving agents are chosen with manufacturing use in mind. They are relatively inexpensive and readily recoverable in high yield after completion of the resolution. In industrial practice, the quantity of resolving agent is often less than the stoichiometric amount, which allows for better separation of the desired enantiomer at a lower cost.